Life How long should you grill chicken breast? Here’s how to get the best, safest results July 23, 2022Clare Mulroy, USA TODAYComments Off on How long should you grill chicken breast? Here’s how to get the best, safest results You should make sure chicken breast is cooked to an internal temperature of 165 degrees for about 10 minutes. Grill them between 425 and 450 degrees.